Recently, a Swedish life science company announced that the results of a preliminary, in vitro study indicated that a mouth spray, called ColdZyme, could potentially deactivate SARS-CoV-2—otherwise known as the virus that’s behind the COVID-19 pandemic that’s been sweeping the globe since last 2019.
The company, Enzymatica, stated that the study demonstrated that ColdZyme deactivates SARS-CoV-2 coronavirus by about 98.3 percent, offering a unique protective barrier against harmful viruses like SARS-CoV-2 (and others) by local virus deactivation in the oral cavity.
The study itself was designed to first determine the ability of ColdZyme to deactivate SARS-CoV-2 known to cause the COVID-19 pandemic. For this purpose, a viricidal efficacy suspension test was conducted using ColdZyme against SARS-CoV-2.
The result? SARS-CoV-2 was deactivated by ColdZyme by up to 98.3 percent in about 20 minutes.
ColdZyme is a medical device mouth spray that was initially designed to form a barrier in the oral cavity to help protect against cold viruses. The barrier solution that comprises the device is mainly made up of glycerol and Atlantic cod trypsin.
The intention of the barrier is to help reduce the probability of catching a cold, but it can also help to shorten the duration of a cold if used at an early phase of the infection by forming a thin, protective barrier on the pharyngeal mucous membrane.
Because SARS-CoV-2 actively replicates in the throat and shows high viral shedding (even at a time of mild symptoms), ColdZyme could (when sprayed onto the mouth and throat) potentially lower the risk of infection and decrease the local viral load.
The in vitro study that was conducted on ColdZyme was based on a standardized and validated methodology. Its intention was to determine the feasibility of ColdZyme to deactivate SARS-CoV-2 known to cause COVID-19 pandemic. Further, it was shown that no cytotoxicity was detected for ColdZyme at any dilution tested.
As it stands, the current in vitro results do not directly translate into clinical efficacy. That being said, the results are still piquing the interest of researchers, scientists, doctors, and more. Why? Because ColdZyme is able to effectively deactivate SARS-CoV-2 in vitro, meaning it constitutes a proof-of-principle that can be taken further into clinical studies.
What does this mean? The results indicate that ColdZyme could offer a protective barrier against SARS-CoV-2—even if the study isn’t able to definitively claim that as of it.
Even more interesting? Previous in vitro results using the same methodology demonstrated that ColdZyme is effective against another coronavirus—one known as HCoV-229E. This coronavirus is one of the causes of the common cold and, compared to SARS-CoV-2, belongs to another subgroup within that corona family.
What does this unique result mean? ColdZyme could be effective against a variety of coronaviruses. While this certainly isn’t definitive as of yet, these results do yield the need for further testing and potential clinical efficacy trials.
Spider veins are a common cosmetic concern for many people, causing small, visible veins to appear just beneath the surface… Read More
Digital Signage for Hospitals: Streamlining Communication in Hospitals SEO description: The use of digital signage for hospitals transforms the way… Read More
Oxygen is the most critical element for human survival, and in scenarios where oxygen levels are compromised, having access to… Read More
In the world of competitive sports and bodybuilding, serious athletes are always on the lookout for reliable, high-quality supplements to… Read More
Car accidents can change lives, causing long-term injuries that affect physical health, finances, and emotional well-being. Recognizing these effects is… Read More
Traumatic brain injury (TBI) is a serious condition that can result from various forms of negligence, such as car accidents,… Read More
It sucks to be on a tight budget. You have to pick and choose what you buy at the grocery… Read More
We’ve all laid in bed tossing and turning, not being able to sleep. But what if this is happening to… Read More
Addiction can profoundly impact every aspect of an individual’s life, from their physical health to their relationships, career, and spiritual… Read More
The mental health landscape for teenagers is increasingly concerning. Adolescence is a period fraught with changes—physically, emotionally, and socially—that can… Read More